To reduce the development of drugresistant bacteria and maintain the effectiveness of primaxin i. Imipenem and cilastatin for injection is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase l, with sodium bicarbonate added as a buffer. Imipenemcilastatin injection primaxin side effects. Have your blood work checked if you are on imipenem and cilastatin for a long time. Due to the high antimicrobial activity of primaxin i. Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis infection of the heart lining and valves and respiratory tract including pneumonia, urinary tract, abdominal stomach area, gynecological, blood, skin, bone, and joint infections. Approximately 20% of imipenem and 40% of cilastatin are protein bound. Pronunciation of imipenem with 1 audio pronunciation, 4 translations and more for imipenem. Meropenem is a relatively new drug and more studies need to be published before susceptibilities of one carbapenem can be used to predict the other. Imipenem uses, side effects, substitutes, composition. Dailymed imipenem and cilastatin imipenem and cilastatin. Medline search from 1975 to 1997 and followup of references. Highlights of prescribing information these highlights do not include all the information needed to use primaxinsafely and effectively. Imilan imipenem and cilastatin injection is a potent broadspectrum antibacterial agent for intravenous administration.
It works by killing bacteria or preventing their growth. Laboratory detection of imipenem or meropenem resistance in. Imipenem and cilastatin injection comes as a powder to be mixed with liquid to be injected intravenously into a vein or intramuscularly into a muscle. Imipenemcilastatin by injection national library of. This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Imilan is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase l with sodium bicarbonate added as buffer. Do not use this medicine in larger or smaller amounts or for longer than recommended. Imipenem binds to and inactivates penicillinbinding proteins pbps located on the inner membrane of the bacterial cell wall.
While generally safe and effective when prescribed by a veterinarian, imipenemcilastatin can cause side effects in some animals. Do not use imipenem if you are allergic to any of its ingredients, to amidetype local anesthetics like lidocaine, or to. The dose recommendations for primaxin represent the quantity of imipenemcilastatin to be administered. Find information about common, infrequent and rare side effects of imipenemcilastatin intravenous. Inem 500mcg injection side effects usages composition. The daily dose of primaxin should be based on the type of infection and given in equally divided doses based on consideration of degree of susceptibility of the pathogens and the patients renal function see also section 4. Know imipenem uses, side effects, dosage, contraindications, benefit, interactions, purpose, drug interactions, precautions, warnings. Written by clinical pharmacology expert mark papich, this handy reference. Common and rare side effects for imipenemcilastatin intravenous.
Imipenem and cilastatin for injectable suspension is a formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase i. Accidental release measures contain spill and collect, as appropriate. Do not use v penum injection if you are allergic to any of its ingredients, to amidetype local anesthetics like lidocaine, or to carbapenem antibiotics. Inem 500mcg injection contain cilastatin, imipenem as generic. Imipenem and cilastatin injection drug information. Common and rare side effects for imipenemcilastatin. V penum injection is used to treat bacterial infections by impeding the growth of the bacterias cell wall. Antiinfective pregnancy risk category c action acts against many grampositive and gramnegative organisms by binding to bacterial cell wall, causing cell death. Imipenem and cilastatin sodium definition of imipenem and. Mean imipenem concentrations remained above a mic of 0. Iminem 500mg injection buy online at best prices with free delivery all over india. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Find details of companies offering imipenem cilastatin injection at best price.
Primaxin imipenem and cilastatin for injection, for intravenous use initial u. Imipenem is a more common cause of seizures than other betalactam antibiotics, particularly when high doses are given 28 c, 29 ar. Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis infection of the heart lining and valves and respiratory tract including pneumonia, urinary tract, abdominal stomach area, gynecological, blood, skin. Imipenem uses, side effects, substitutes, composition and. This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. Imipenem is the first available semisynthetic thienamycin and is administered intravenously in combination with cilastatin, a renal dipeptidase inhibitor that increases urinary excretion of active drug.
The dosage recommendations for primaxin represent the quantity of imipenem to be administered. Imipenem and cilastatin sodium reconstituted with lidocaine hydrochloride for i. Cilastatin sodium, an inhibitor of this enzyme, effectively prevents renal metabolism of imipenem so that when imipenem and cilastatin sodium are given concomitantly. Imipenem is a broadspectrum, semisynthetic betalactam carbapenem derived from thienamycin, produced by streptomyces cattleya. When imipenem and cilastatin is injected intravenously, it is usually infused injected slowly over a period of 20 minutes to 1 hour every 6 or 8 hours. Because imipenem is rapidly inactivated by renal dehydropeptidase i, it is given in combination with cilastatin, a dhpi inhibitor which increases halflife and tissue penetration of imipenem. May 09, 2019 meropenem is slightly more active than imipenem against gramnegative organisms. Imipenem and cilastatin for injection is a powder containing imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase i. The safety of imipenemcilastatin has not been established for animals that are pregnant or lactating.
Saunders handbook of veterinary drugs sciencedirect. Jan 01, 2017 imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. Imipenem and cilastatin for injection, chemical structure. Read more about the prescription drug imipenemcilastatin injection. Clinical trials comparing imipenem with meropenem, or either. Imipenem, when administered alone, is metabolized in the kidneys by dehydropeptidase i resulting in relatively low levels in urine. Imipenem is a betalactam antibiotic that is used in combination with cilastatin to treat infections such as lower respiratory tract infections, urinary tract infections, intraabdominal infections, bacterial septicemia, etc.
Imipenem is used to treat bacterial infections by impeding the growth of the bacterias cell wall. Saunders handbook of veterinary drugs, 4th edition includes entries for 550 drugs, with convenient appendices summarizing clinically relevant information at a glance. I nem500mg mainly use for abdominal sepsis, advanced prostate cancer, bone and joint infection, brain abscesses, cellulitis, diabetic foot ulcer, endocarditis, gastric acid reduction during general anaesthesia, gynecological infections, lower respiratory tract infections, obstetric infections, peritonitis and the side effects. Laboratory detection of imipenem or meropenem resistance. Addition of cilastatin prevents renal inactivation of imipenem, resulting in increased. Imipenem cilastatin injection in delhi, delhi dealers. What are some things i need to know or do while i take imipenem and cilastatin. Nov 09, 2018 imipenem is an antibiotic that fights bacteria.
Pharmaceutical injection imipenem injectable products. Minimum inhibitory concentrations mcgml disk diffusion zone diameter in mm. The absorption of imipenem from the im injection site continues for 6 to 8 hours while that for cilastatin is essentially complete within 4 hours. Imipenem definition is a semisynthetic carbapenem antibiotic c12h17n3o4sh2o that is derived from a bacterium streptomyces cattleya and is effective against gramnegative and grampositive bacteria. Imipenem is distributed into most body tissues and fluids including heart valve, bone, uterus, ovary, intestine, saliva, sputum, bile, as well as peritoneal, pleural, and wound fluids. For intravenous injection only the dosage of primaxin in adult patients should be based on suspected or confirmed pathogen susceptibility as shownin table 1 below. An equivalent amount of cilastatin is also present in the solution. Dec 11, 2019 what are some things i need to know or do while i take imipenem and cilastatin. I nem injection 500mg500mg1vial 1vial injection imipenem and cilastatin drug information. Iminem injection is used for bacterial infections, infections during or after delivery management of fever, patients with reduced immunity due to low white blood cells, lower respiratory tract infections, urinary tract infections, intraabdominal infections, gynecologic infections, bacterial septicemia, bone and joint infections, skin and skin structure infections and other conditions. Pbps are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and. This medicine will not work for colds, flu, or other virus infections.
In the workplace, this material should be considered potentially. This drug must be given by intramuscular injection or intravenous infusion because it is not absorbed from the gastrointestinal tract. Imipenem and cilastatin for injection is a sterile mixture of imipenem, cilastatin sodium, and sodium bicarbonate. Jun 11, 1997 to compare and contrast imipenem and meropenem in terms of in vitro activity, pharmacokinetics, clinical efficacy and adverse effects. New to this edition are 25 new drug monographs and easy access to drug content on any mobile device. It is a broadspectrum antibacterial agent given by intravenous administration.
Some health conditions may make you more susceptible to the sideeffects of the drug. Imipenem is commonly used in combination with and is now available in a tripledrug product with cilastatin and which was recently approved by the fda. Contraindications and precautions contraindicated in patients hypersensitive to drug. I nem500mg injection contain cilastatin, imipenem as generic. This includes your doctors, nurses, pharmacists, and dentists. Do not use imipenem if you are allergic to any of its ingredients, to amidetype local anesthetics like lidocaine, or to carbapenem antibiotics. Imipenem and cilastatin for injection is a sterile mixture of imipenem,cilastatin sodium,and sodium bicarbonate. Imipenem cilastatin is a potent broad spectrum antibacterial agent for intravenous administration. Imipenem is a broadspectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Imipenemcilastatin side effects, dosage, interactions.
Imipenem would be predicted to be effective for the treatment of antimicrobial resistant bacterial infections in cats at a dosage of 5 mgkg every 68 h iv, im, or longer for the sc route. Imipenem and cilastatin is a potent broad spectrum antibacterial agent for intravenous administration. Do not use v penum injection if you are allergic to any of its ingredients, to amidetype local anesthetics like. Tell all of your health care providers that you take imipenem and cilastatin. Find information about common, infrequent and rare side effects of imipenem cilastatin intravenous. Imipenem and cilastatin for injection usp page 1 of 43 product monograph pr imipenem and cilastatin for injection usp imipenem and cilastatin for injection imipenem cilastatin sodium, 250 mg250 mg for injection imipenem cilastatin sodium, 500 mg500 mg for injection sterile powder for iv infusion must be diluted before use. Inem 500mcg mainly use for abdominal sepsis, advanced prostate cancer, bone and joint infection, brain abscesses, cellulitis, diabetic foot ulcer, endocarditis, gastric acid reduction during general anaesthesia, gynecological infections, lower respiratory tract infections, obstetric infections, peritonitis and the side. Imipenem and cilastatin for injection primaxin is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase l, with sodium bicarbonate added as a buffer.
I nem injection imipenem and cilastatin drug price and. In vitro studies have demonstrated that imipenem has an extremely wide spectrum of antibacterial activity against gramnegative and gram. Cilanem 500 injection uses, dosage, side effects, price. Cilanem 500 injection is a combination medicine used to treat infections of the lower respiratory tract, urinary tract, bone and joints, blood, intraabdominal infections, skin and soft tissue infections, etc. Get best price deals on imipenem cilastatin injection in delhi, delhi. Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other betalactams. Primaxin iv injection summary of product characteristics. I nem500mg injection side effects usages composition.
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